IntroductionSpores of the bacterium Bacillus subtilis (B.subtilis) have been shown to carry a number of properties potentially beneficial for vaccination.Firstly, as vehicles enabling mucosal delivery of heterologous antigens and secondly, as stimulators of innate immunity.Here, we have examined the specificity of protection conferred by the spore-
BackgroundE-cadherin, a hallmark of epithelial-mesenchymal transition (EMT), is often repressed due to Snail-mediated epigenetic modification; however, the exact mechanism remains unclear.There is an urgent need to understand the determinants of tumor aggressiveness and identify potential therapeutic targets in breast cancer.Experimental designWe s
With the development of nanomedicine technology, stimuli-responsive nanocarriers play an increasingly important role in antitumor therapy.Compared with the normal physiological environment, the tumor microenvironment (TME) possesses several unique properties, including acidity, high glutathione (GSH) concentration, hypoxia, over-expressed enzymes a
The quantification and molecular characterization of the AdV genome in urban wastewater samples (WWSs) collected weekly Kitchen Knives at a wastewater treatment plant (WWTP) in Milan from 1 January 2021 (week 2021-01) to 1 May 2022 (week 2022-17) were performed.The concentration of the AdV genome was graphically compared with the AdV positive rate
Obtaining high and stable yields of tomato with good consumer qualities in the open field has now become problematic due to the fact that hybrids and varieties of tomato of an intensive type place high demands on the presence of moisture and nutrients in the root-soil layer.The required level of soil moisture in combination with the introduction of